Sclerodermatous Graft-versus-Host Disease Arsenic Trioxide Prevents Murine

Human Scleroderma Graft-Versus-Host Disease: A Model for Lung Fibrosis in Murine Sclerodermatous Treatment Prevents Skin and β Anti-TGF-

Imatinib for sclerodermatous graft-versus-host disease in lung transplantation.

Imatinib has been proposed as a treatment for sclerodermatous chronic graft-versus-host disease (GVHD) due to its antifibrotic activity. Because imatinib has a potentially adverse effect on wound healing, the safety of its perioperative use in lung transplantation is unknown. Herein, we present a patient who underwent bilateral living-donor lobar lung transplantation for pulmonary complications ...

UVA1 Phototherapy in the Management of Sclerodermatous Graft-Versus-Host Disease (GVHD): a report of two cases

Chronic graft-versus-host disease (GVHD) is a frequent complication after allogeneic hematopoietic stem cell transplantation (HSCT). Approximately 10% of patients with GVHD develop sclerodermatous changes, which can cause significant morbidity and are often refractory to standard systemic immunosuppression. We present two cases of sclerodermatous GVHD. The first is a 39-year-old man, who had a ...

Calcinosis Cutis Related to Sclerodermatous Chronic Graft Versus Host Disease

We present the case of a 54-year-old woman who had calcinosis cutis related to sclerodermatous chronic graft versus host disease. Graft versus host disease had developed following stem cell transplantation for acute myelogenous leukemia 14 years earlier, but was shown by skin biopsy to have resolved by the time of presentation. Radiographs showed extensive cutaneous calcifications in the lower ...

STAT3 signaling in CD4+ T cells is critical for the pathogenesis of chronic sclerodermatous graft-versus-host disease in a murine model.

Donor CD4+ T cells are thought to be essential for inducing delayed host tissue injury in chronic graft-versus-host disease (GVHD). However, the relative contributions of distinct effector CD4+ T cell subpopulations and the molecular pathways influencing their generation are not known. We investigated the role of the STAT3 pathway in a murine model of chronic sclerodermatous GVHD. This pathway ...